Neglected diseases and drug discovery by Michael J Palmer; Timothy N C Wells

By Michael J Palmer; Timothy N C Wells

Content material: Malaria; Trypanosomatids; TB; Flavivirus dependent ailments (Dengue fever, Yellow fever, West Nile virus); Helminth, nematode and schistosoma dependent illnesses; HIV reduce respiration tract an infection; Diarrhea

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Garcia-Bustos, Nature, 2010, 465, 305. 62. W. A. Guiguemde, A. A. Shelat, D. Bouck, S. Duffy, G. J. Crowther, P. H. Davis, D. C. Smithson, M. Connelly, J. Clark, F. Zhu, M. B. Jime´nez-Dı´ az, M. S. Martinez, E. B. Wilson, A. K. Tripathi, J. Gut, E. R. Sharlow, I. C. Bathurst, F. El Mazouni, J. W. Fowble, I. Forquer, P. L. McGinley, S. Castro, I. Angulo-Barturen, S. Ferrer, P. J. Rosenthal, J. L. Derisi, D. J. Sullivan, J. S. Lazo, D. S. Roos, M. K. Riscoe, M. A. Phillips, P. K. Rathod, W. C. Van Voorhis, V.

Falciparum. Some of these compounds are ready for testing in humans and have been shown to be safe, so it should be possible to rapidly evaluate the target in human malaria. Another set of key pathways to be utilised as drug targets occur in the apicoplast in Plasmodium. 84 These pathways should offer targets that have a high degree of selectivity. The best studied is the 1-deoxy-d-xylulose 5-phosphate (DOXP) pathway for isoprenoid biosynthesis, which is the target of fosmidomycin, now in Phase II clinical trials in combination with other antimalarials.

S. Buckner, E. Fan, A. Lauricella, G. DeTitta, J. Luft, F. Zucker, W. G. Hol, C. L. Verlinde and E. A. Merritt, J. Mol. , 2008, 381, 975. 82. E. A. Taylor Ringia and V. L. Schramm, Current Topics in Medicinal Chemistry, 2005, 5, 1237. 83. D. C. Madrid, L. M. Ting, K. L. Waller, V. L. Schramm and K. J. Kim, J. Biol. , 2008, 283, 35899. 84. R. F. Waller and G. I. McFadden, Curr. Issues Mol. , 2005, 7, 57. 85. J. S. Freundlich, F. Wang, H. C. Tsai, M. Kuo, H. M. Shieh, J. W. Anderson, L. J. Nkrumah, J.

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