Intestinal Absorption by Bengt Borgström (auth.), D. H. Smyth (eds.)

By Bengt Borgström (auth.), D. H. Smyth (eds.)

It will be requested if there's a desire for yet one more huge overview on Intestinal Absorption, and the answer's that this can be nonetheless a speedily increasing box of curiosity either from the clinical and medical issues of view. there's abundant proof for this within the variety of papers which stay released, and the bul­ letin on Intestinal Absorption issued via the Biomedical Infor­ mation undertaking of the collage of Sheffield lists approximately a hundred and fifty titles per 30 days, and there's nonetheless no signal of any diminution during this price. There are in truth such a lot of papers that these drawn to intestinal absorption need to be experts in a single specific box, yet needs to even as concentrate on the final deve­ lopments within the topic as a complete. The final significant overview used to be the wonderful quantity within the American instruction manual released in 1968, already six years in the past, and certainly many of the con­ tributors to that quantity have taken half within the current paintings. a few observations made within the advent to a quantity of the British clinical Bulletin on Intestinal Absorption a few years in the past are nonetheless pertinent. development within the experimental sciences isn't non-stop, yet proceeds in levels of speedy growth regulate­ nating with classes of slower growth.

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The nature of the mechanism is not known but may depend on the metabolic integrity of the cell membrane [112]. The results so far obtained indicate, however, that in vitro experiments used with such success in the elucidation of the mechanism of carbohydrate absorption, may not give information about lipid absorption necessarily relevant to the in vivo situation. This important reservation should be considered in the planning and interpretation of experiments aiming at the elucidation of the mechanism of fat absorption.

The possibility also exists that the presence of bile salt may increase the rate of transfer of fatty acids from an oil phase to the micellar phase. Other amphiphilic solutes with a lower water solubility than the long chain fatty acids are less well absorbed in vivo from dispersions in bile salt solution at low concentration. For such substances a more definite increase of rate of absorption is seen in the micellar region, indicating the importance of the micellar phase for their uptake into the cell.

The triglyceride fat is ingested more or less emulsified, the emulsion stabilized by a surface film of phospholipids, glyco- 582 BENGT BORGSTROM lipids or protein. A certain degree of hydrolysis may take place in the lumen of the stomach, especially of short and medium chain fatty acids. The stomach content is delivered in fractions to the duodenum where it is mixed with bile and pancreatic juice and is then carried further down the intestine. At the same time the triglyceride fat is hydrolysed by the action of lipolytic enzymes of pancreatic juice.

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