Human Oral Mucosa, 1st Edition by Christopher Squier, Kim Brogden

By Christopher Squier, Kim Brogden

Human Oral Mucosa: improvement, constitution and serve as is a brand new textual content that displays the substantial elevate in wisdom of oral mucosa that has happened in recent times. Our realizing of the constitution of oral mucosa is now tested at a molecular instead of a tissue or mobile point.

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Human Oral Mucosa, 1st Edition

Human Oral Mucosa: improvement, constitution and serve as is a brand new textual content that displays the substantial raise in wisdom of oral mucosa that has happened in recent times. Our figuring out of the constitution of oral mucosa is now verified at a molecular instead of a tissue or mobile point.

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A nevus (mole) is a benign proliferation of melanocytes and in the oral cavity that is not easy to distinguish clinically from melanoma. It should be completely removed. Melanoma is a malignant tumor of melanocytes. In the oral cavity, melanoma is rare, but prognosis is poor, with a 5-year survival rate of 10%–20%. Treatment is surgical removal. One of the most common exogenous pigments is amalgam accidentally forced into the gingiva during placement of a restoration. This circumstance gives rise to patches of bluish gray discoloration known as amalgam tattoo.

1 ORGANIZATION OF THE NORMAL INTERFACE In routine hematoxylin and eosin stained histological sections of oral mucosa, the basement membrane between the epithelium and connective tissue appears as a structureless band, but it stains brightly with reagents such as periodic acid-Schiff (PAS) which detects glycogen, neutral mucosubstances, glycolipids, and phospholipids (Fig. 1A). Ultrastructurally, this region is described as the basal lamina or basal complex and is highly organized (Fig. 2). It consists of a layer of finely granular or filamentous material about 50 nm thick, the lamina densa, which runs parallel to the basal cell membranes of the epithelial cells but is separated from them by an apparently clear zone some 45 nm wide, the lamina lucida.

1998). Lymphocytes are often associated with Langerhans cells, which are able to activate T lymphocytes. Thus, keratinocytes produce cytokines which modulate the function of Langerhans cells. In turn, the Langerhans cells produce cytokines such as IL-1, which can activate T lymphocytes so that 50 Human Oral Mucosa they are capable of responding to antigenic challenge. IL-1 also increases the number of receptors to melanocytestimulating hormone in melanocytes and so can affect pigmentation. The influence of keratinocytes extends to the adjacent connective tissue, where cytokines produced in the epithelium can influence fibroblast growth and the formation of fibrils and matrix proteins.

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