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1973) Life-cycle depend ence of repair of potentially-lethal radiation damage. Int. J. Radiat. Biol. 23, 401-407. Little, J. , Hahn, G. , and Tubiana, M. (1973) Repair of potentially lethal damage in vitro and in vivo. Radiology 106, 689-694. Masuda, K. (1968) Effects of 14 MeV neutrons on the reproductive capacity of HeLa S3 cells. J. Radiat. Res. 9, 116-128. Mottram, J. C. (1936a) A factor of importance in the radio sensitivity of tumors. Br. J. Radiol. 9, 606-614. Mottram, J. C. (1936b) On the spacing of radiation accord ing to variation in radio-sensitivity.
The details of particle interactions are discussed in later chapters. 2 Biological Effects of High-LET Radiations II. 41 INTERACTION OF HEAVY PARTICLES WITH TISSUE The characteristic difference between the interaction of X rays or gamma rays and that of fast neutrons with tissue is in the resultant charged particles set in motion. In the case of gamma rays, electrons are released, whereas fast neutrons release protons, alpha particles, and heavier recoil nuclei. For a given particle, the LET of charged particles increases with increasing particle charge and decreasing velocity.
As discussed in the previous section, these differences could be due to different energy density distributions in the particle 2 2 (1970) found that, tracks used by Barendsen and Todd. Curtis if OER is plotted as a function of Z * / P (where Z* is the effective charge of the particle and p is the ratio of the velocity of the particle and the velocity of light) instead of LET, then the data of Barendsen and Todd appear to be consistent. ( 1966) 0 500 1000 Dose ( r a d ) 1500 2000 Fig. 2-7. 2 (redrawn from Barendsen and his associates, 1966).