Genetics of Influenza Viruses by E. D. Kilbourne (auth.), Professor Dr. Peter Palese,

By E. D. Kilbourne (auth.), Professor Dr. Peter Palese, Professor Dr. David W. Kingsbury (eds.)

With the arrival of genetic engineering equipment and more suitable biochemical tech­ niques, a lot has been discovered concerning the replication of influenza viruses, their constitution and their epidemiology. it seems that the time is ripe to check those efforts and to supply a molecular point of view of influenza virology. it truly is was hoping that this ebook will stimulate our pondering, aid us in designing new experiments, and doubtless express avenues resulting in the keep watch over of the illnesses linked to influenza viruses. Peter Palese, ny, N. Y. August 1983 David W. Kingsbury, Memphis, Tenn. Contents record of individuals. . . . . . . . . . . . . . . . . XV 1. The Evolution of Influenza Viral Genetics - A viewpoint. by way of E. D. Kilbourne. . . . . . . . . . . . . . . . 1 I. creation. . . . . . . . . . . . . . . . . 1 II. the advance of recent Influenza Viral Genetics 2 A. Early facts of Genetic version within the Laboratory 2 B. program of Formal Genetic ideas to reports of Influenza Virus . . . . . . . three C. Genetic Markers. . . . . . . . . three D. improvement of Plaquing platforms. . . four E. using Conditional deadly Mutants five F. New methods in Influenza Virus Genetics. 6 1. The Biochemical id of Viral Gene items within the Unambiguous Definition of Viral Inheritance . . . 6 2. Mapping of the Influenza Virus Genome via Correlative Physico-Chemical and organic suggestions. . . . . . 7 three. the applying of Molecular organic concepts to the examine of Viral Genetic edition. . . . . . . . . eight four. Oligonucleotide Mapping of Viral RNA's . . . . . . . eight five. Contribution of Protein and RNA Sequencing to Influenza Viral Genetics-Intragenic Mapping . . . . . . . eight III. Viral Genetics and the knowledge of Viral Virulence and Pathogenicity . . . . . . . . . . . . . . . . . . .

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Virology 102, 412-419 (1980). : Agglutination of red cells by allantoic fluid of chick embryos infected with influenza virus. Science 94, 22-23 (1941). Hirst, G. : Genetic recombination with newcastle disease virus, polioviruses, and influenza. Cold Spring Harbor Symp. on Quant. bioI. 27, 303-309 (1962). : Mechanism of influenza recombination. I. Factors influencing recombination rates between temperature-sensitive mutants of strain WSN and the classification of mutants into complementation-recombination groups.

75, 6258-6262 (1978). Kilbourne, E. : Molecular epidemiology-influenza as archetype. The Harvey Lectures 73,225-258 (1979). Kilbourne, E. : Influenza: Viral determinations of the pathogenicity and epidemicity ofan invariant disease of variable occurrence. Phil. Trans. R. Soc. ) B 288, 291-297 (1980). Kilbourne, E. : Recent contributions of molecular biology to the clinical virology of myxoviruses. Yale]. BioI. Med. 53, 41-45 (1980). Kilbourne, E. : Segmented genome viruses and the evolutionary potential of asymmetrical sex.

Noble, G. , Dowdle, W. : Laboratory-based surveillance of influenza virus in the United States during the winter of1977-1978. II. ,]anuary 1978. ]. ll0, 462-468 (1979). Kilbourne, E. ]. Exp. Med. 101, 437-450 (1955). Kilbourne, E. : The influence of cortisone on experimental viral infection. IV. ]. Exp. Med. 106, 863-881 (1957). Kilbourne, E. : Influenza virus genetics. Progr. Med. Virol. 5, 79-126 (1963). Kilbourne, E. : Recombination of influenza A viruses of human and animal origin. Science 160, 74-76 (1968).

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