Genes and health, Edition: 3ed by Playfair D.

By Playfair D.

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Small wonder, then, that targets are the most sought-after and fought-over objects in medical research. New methods make the search for targets faster, safer and more effective and thereby lead to advances in medicine, since every new target is another ray of hope in the fight against diseases. They are the ‘stars’ of medicine. Everywhere they are sought after, pursued and adored. Whenever they are found, they become an object of feverish research. Scarcely any other area of biological research is being pursued with such financial backing and intellectual effort as the search for ‘targets’ for new drugs.

Slightly different variants that lie extremely close together in the two-dimensional gel. In order to permit identification of these less common variants as well, two-dimensional gel electrophoresis is generally complemented by other separation methods. For example, components of the sample to be analysed can be separated in advance by filtration or centrifugation. g. charge, size, shape or binding behaviour. And the 2-D gel electrophoresis itself can be further refined by limiting both of the separation factors that it employs, namely charge and size, to a certain range within which resolution is particularly high.

Glycogen deposition Molecules that play key roles in metabolism are potential drug targets. With the exception of sugars, such molecules offer medicine only very nonspecific targets for drug action. Moreover, most of them are formed and broken down very rapidly in the body and play only a minor role in metabolism as compared with proteins, in particular. Under some circumstances, however, it can be useful to bind a specific intermediate product of an undesirable metabolic pathway and thereby block production of the end-product of that pathway.

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