Ciba Foundation Symposium - Isotopes in Biochemistry

Chapter 1 Chairman's commencing feedback (pages 1–3): A. S. McFarlane
Chapter 2 Metabolism of 14C?Labelled Steroids (pages 4–13): C. P. Leblond
Chapter three excessive ldl cholesterol content material of Human Spleen (pages 14–16): Karl Bernhard
Chapter four The Biosynthesis of Radioactive ldl cholesterol via Surviving Liver Slices (pages 17–27): Samuel Gurin and Roscoe O. Brady
Chapter five reports with Deuterium Steroids (pages 28–40): T. F. Gallagher
Chapter 6 The Biosynthetic Mechanism of Porphyrin Formation (pages 41–67): David Shemin and Jonathan Wittenberg
Chapter 7 reviews on Mammalian purple Cells (pages 68–85): A. Neubergeb
Chapter eight initial Investigations for a examine of strength used by the Surviving poultry Erythrocyte in H?m Synthesis (pages 86–89): C. Rimington
Chapter nine Iron Metabolism in Pathological stipulations (pages 90–95): A. Vannotti
Chapter 10 The amendment of X?Ray Sensitivity by way of chemical substances (pages 96–113): Alexander Hollaender, G. E. Stapleton and W. T. Burnett
Chapter eleven impression of X?Rays on Nucleic Acid and Protein Synthesis within the Jensen Rat Sarcoma (pages 114–121): Barbara E. Holmes
Chapter 12 Radiation Dose in Tracer Experiments related to Autoradiography (pages 122–137): S. R. Pelc
Chapter thirteen Synthesis of Deoxyribose Nucleic Acid and Nuclear Incorporation of 35S as proven by means of Autoradiographs (pages 138–151): Alma Howard and S. R. Pelc
Chapter 14 The Biosynthesis of Pyrimidines in vitro (pages 152–163): D. Wright Wilson
Chapter 15 experiences with natural? and Bio?Synthetic Nucleosides and Nucleotides (pages 164–174): G. B. Brown
Chapter sixteen using Radiophosphorus within the research of the Nucleic Acids (pages 175–183): J. N. Davidson
Chapter 17 fee of Synthesis and Quantitative diversifications of the Ribonucleic Acid through the development of a tradition of Polytomella Coeca (pages 184–189): R. Jeener
Chapter 18 a mode for the review of the speed of Protein Synthesis in guy (pages 190–202): D. Rittenberg
Chapter 19 Turnover charges in the course of Formation of Proteins and Polynucleotides in Regenerating Tissues (pages 203–212): E. Hammarsten
Chapter 20 Synthesis of Phenylalanine and Tyrosine in Yeast (pages 213–226): Konrad Bloch
Chapter 21 A learn of Acetone Metabolism utilizing Glycogen and Serine as signs, and the function of C1?Compounds in Metabolism (pages 227–245): Harland G. Wood
Chapter 22 uneven Citric Acid (pages 246–257): Charles Heidelberger and Van R. Potter
Chapter 23 Mode of Formation of Fatty Acids from Acetate and Glucose as Studied within the Mammary Gland (pages 258–284): G. Popjak

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Pyrrole rings A and B Pyrrole rings C and D ........... Pyrrole rings A+B+C+D 4 Methene Bridge carbon atoms .. .... ............ Total Activity wm 5236 1290 1324 2614 2620 48 DAVIDSHEMINAND JONATHAN WITTENBERG CZ, D2, the alpha carbon atom of the pyrrole ring on the side of the vinyl and propionic acid side chains, were derived from the a-carbon atoms of glycine (Fig. 3). The findings that the activities of Rings A and B is equal to that of Rings C and D and that the carbon atoms in the pyrrole rings derived from glycine are in comparable positions (underneath the longer side chains) supports the earlier suggestion of a common precursor pyrrole.

5 atoms of deuterium per molecule less than the cholesterol. Conversely, when cholesterol is saturated with deuterium in acetic acid-d more than the expected 2 atoms of D appear in the product. This means, we feel, that when carbon atom 6 forms a complex with the catalyst, the hydrogen or deuterium at that position becomes labile and exchanges with the hydrogen or deuterium of the medium. You must have hydrogen gas to achieve this because in the absence of reduction no change or only a very minor one occurs.

Androst-Z-en-17-one ..... Androstane-3:17-dione . . . Btiocholane-3:l7-dione . . . . . . Subtract “endogenou~”products Isotopic metabolites recovered ... ...... ...... ...... Total ...... ...... ...... ...... ...... ...... 08 The values for the quantitatively minor ketonic metabolites were obtained by isotopic dilution alone since the amounts were too small t o permit direct isolation. In these instances, 38 T. F. GALLAGHER the endogenous production can be disregarded without error since it is very small in comparison with the amount of carrier added.

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