Champions of Darkness (Sword & Sorcery Ravenloft) by Beth Bostic, Carla Hollar, Tadd McDivitt

By Beth Bostic, Carla Hollar, Tadd McDivitt

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15] shown in Fig. 6(a) show that a second surge in activity occurs as the propofol concentration dissipates, allowing the patient to re-emerge into consciousness. Thus there are two biphasic peaks per induction–emergence cycle: the first at or near loss-of-consciousness (LOC), and the second at recovery-of-consciousness (ROC). The onset of the first EEG surge lags ∼2 min behind the rise in propofol concentration; this delay arises because of the unavoidable mismatch between the site of drug effect (the brain) and the site of drug measurement (the blood)—it takes about 2 min for the drug to diffuse across the blood–brain barrier.

White curve shows distribution of stable (solid line) and unstable (dashed line) steady states. Saddle–node bifurcation points SN1 , SN2 are marked with open circles (◦). 05 mV/ms (white). Saddle–node ghosts form in the “shadow zone” that projects beyond the turning points. ) Steyn-Ross, Steyn-Ross, Wilson, and Sleigh SN2 −10 −15 Sleep −20 1 2 3 4 Dv (mV) where ε = |Dv − D0v | measures the distance to the saddle–node bifurcation point. This theoretical prediction has been verified by numerical simulation—see Fig.

References 1. : Statistical Methods in Quantum Optics: Master Equations and Fokker–Planck Equations. Springer, Berlin New York (1999) 2. : Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states. J. Neurosci. 19(11), 4595–4608 (1999) 3. : Smoothing and interpolation with finite differences. S. ), Graphic Gems IV, pp. 241–250, Academic Press, San Diego, CA, USA (1994) 1 Evidence for neural phase transitions 25 4. : Anaesthetics set their sites on ion channels.

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