By Haim Tal
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Extra resources for Bone Regeneration
Cell therapies involve the use of any kind of cells to repair damaged or destroyed bone cells or tissues, and are unique in that the active component consists of living cells. Autologous Cell Therapies for Bone Tissue Regeneration 27 One of the biggest cell therapy areas is tissue engineering, defined by Langer and Vacanti (1993) as an interdisciplinary field that applies the principles of engineering and the life sciences to the development of biological substitutes that restore, maintain or improve tissue function.
Vascularization of an implanted graft can also be accelerated by the utilization of angiogenic factors. , 2003). Incorporation of these factors into scaffolds and control of their local release rate and delivery regime is one possibility for accelerating vascular in-growth in vivo. Another way of achieving vascularization of tissue engineered bone grafts is co-culturing endothelial and osteogenic cells into bone constructs engineered in vitro – the so called in vitro prevascularization approach.
2007). Long-bone critical-size defects treated with tissue-engineered grafts: a study on sheep. J Orthop Res, 25(6), 741-749. Wagner, W; Wein, F; Seckinger, A; Frankhauser, M; Wirkner, U; Krause, U; Blake, J; Schwager, C; Echstein, V; Ansorge, W; Ho, A. (2005). Comparative characterisitcs of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol, 33(11), 1402-1416. , & Thampatty, B. (2008). Mechanobiology of adult and stem cells. Int Rev Cell Mol Biol, 271, 301-346.